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Kisspeptin-10: A bioactive decapeptide used to activate the KISS1R (GPR54) in studies of neuroendocrine signaling and GnRH neuronal dynamics.
$105.00
Out of stock
Kisspeptin 10 also known as Kp 10 is a synthetic decapeptide derived from the C terminal bioactive fragment of the KISS1 gene product. It is supplied as a research grade peptide for use in neuroendocrine biology cellular signaling and receptor pharmacology studies. This material is intended for qualified investigators who require a defined source of a KISS1R activating ligand.
Kisspeptin 10 is the shortened bioactive fragment of kisspeptin peptides that engage the KISS1 receptor also designated as GPR54. The KISS1R is a G protein coupled receptor expressed across neuroendocrine and peripheral tissues. In preclinical and research settings Kisspeptin 10 is used as a tool compound to investigate KISS1R activation and downstream signaling outcomes.
These typically include second messenger systems gene expression changes and functional responses in isolated cells and tissue preparations. Kisspeptin signaling pathways have been examined in model systems that study hypothalamic neurons pituitary function metabolic regulation vascular biology and cellular adhesion dynamics.
This work aims to clarify the roles of KISS1R in various physiological contexts using controlled experimental designs.
This product is intended exclusively for in vitro experiments ex vivo preparations and other controlled laboratory research applications. It may be used as a reference ligand or tool compound in studies of G protein coupled receptor signaling neuroendocrine pathway regulation and related areas of cell and tissue biology. It is not intended for human or veterinary use.
It is not intended for diagnosis treatment cure prevention or mitigation of any disease or medical condition. It is not a drug food dietary supplement cosmetic or medical device.
Synthetic kisspeptin 10 decapeptide suitable for KISS1R activation studies Applicable in receptor binding assays second messenger signaling assays and gene expression work
Manufactured under controlled conditions with analytical verification of identity and purity
Kisspeptin peptides also referred to as KISS1 derived ligands or metastin are endogenous signaling molecules studied across vertebrate neuroendocrine and cellular systems.
Kisspeptin 10 is a short C terminal fragment that retains high affinity and functional activity at the KISS1 receptor KISS1R also known as GPR54. The information in this section summarises how Kisspeptin 10 is used as a tool compound in the scientific literature. All observations are model specific and do not constitute safety or efficacy claims for any therapeutic use.
A primary focus of kisspeptin research is the control of reproductive axis signaling. In preclinical models Kisspeptin 10 is frequently used to study activation of hypothalamic gonadotropin releasing hormone GnRH neurons. Experimental systems include brain slice preparations immortalised neuronal lines and in vivo rodent models where electrophysiology calcium imaging and immediate early gene markers are used to track GnRH neuron responses to Kisspeptin 10 exposure.
These studies help map KISS1R positive circuits and clarify how kisspeptin input integrates with other neuroendocrine signals regulating reproductive hormone release.
Downstream of GnRH neurons Kisspeptin 10 has been used to probe pituitary function in animal and cell based models.
Researchers examine how KISS1R signaling influences the timing and amplitude of gonadotropin secretion by measuring luteinizing hormone and follicle stimulating hormone responses in controlled settings. These investigations often combine Kisspeptin 10 administration with pharmacologic blockers or genetic manipulations to separate hypothalamic level effects from direct pituitary actions. The resulting data support mechanistic models of how kisspeptin contributes to pulse generation and feedback regulation in the reproductive axis.
Kisspeptin pathways intersect with metabolic signaling which has led to their use in studies connecting energy status to reproductive control. Preclinical work uses Kisspeptin 10 in hypothalamic and peripheral models to examine cross talk with leptin insulin and other metabolic hormones. Endpoints can include changes in neuropeptide expression feeding related behaviors and metabolic biomarkers in animals under different nutritional states. In this context Kisspeptin 10 serves as a tool to probe how KISS1R expressing neurons integrate metabolic and reproductive cues.
Beyond the central nervous system kisspeptin signaling has been examined in vascular and peripheral tissues. Kisspeptin 10 is used in endothelial cell cultures vascular smooth muscle cells and ex vivo vessel preparations to study receptor expression second messenger activation and functional responses such as contractility and permeability.
These experiments evaluate how KISS1R activation influences vascular tone cell proliferation and interactions with other vasoactive mediators under defined conditions.
This work is exploratory and aims to position kisspeptin signaling within broader vascular biology frameworks.
KISS1 was originally identified in the context of metastasis research which continues to guide many cell based studies. Kisspeptin 10 is used in tumor cell lines to investigate effects on migration invasion and adhesion. Assays include scratch wound closure transwell migration matrix invasion and adhesion to extracellular matrix components. Researchers track changes in cytoskeletal organization matrix metalloproteinase expression and adhesion molecule profiles following KISS1R activation.
These studies help clarify how kisspeptin pathways might regulate metastatic behavior in experimental oncology models.
Across the literature Kisspeptin 10 is commonly used in neuroendocrine studies of GnRH neuron activation pituitary gonadotropin secretion dynamics
metabolic interface research linking energy balance and reproduction vascular biology and endothelial signaling models tumor cell migration adhesion and invasion assays.
In all these settings Kisspeptin 10 functions as a defined KISS1R ligand to dissect receptor driven pathways in controlled experimental systems.
All findings described here come from in vitro experiments ex vivo preparations and animal studies often within tightly controlled protocols. They are provided solely to inform qualified researchers about how Kisspeptin 10 has been used in scientific investigations.These observations do not demonstrate or imply that Kisspeptin 10 is safe or effective for any human or veterinary indication. They are not dosing instructions medical advice or guidance for fertility treatment metabolic disorders vascular disease or cancer. Kisspeptin 10 supplied by us is intended strictly for laboratory research applications. It is not for human or veterinary use and must not be used for diagnosis treatment cure prevention or mitigation of any disease or condition.
Store peptides only in professional, controlled environments that operate under their own safety and quality systems. All storage, handling, and disposal must follow your organization’s written policies, risk assessments, and standard operating procedures. It is the responsibility of the facility and its staff to ensure that these policies are in place, understood, and actively followed. Keep vials in a cool, dry location away from direct light, heat, and moisture. Vials should remain upright, sealed, and protected from physical impact so contents and labels stay intact and legible. If your procedures include freezing, use appropriate working volumes and avoid repeated freeze and thaw cycles of the same vial. Do not store peptides near food, drink, or general consumables. Keep them only in designated storage areas with controlled access that reflect your internal governance and regulatory obligations. Handling and preparation must be carried out solely by personnel who are trained and authorized under your institutional guidelines.
This product is intended exclusively for in vitro experiments ex vivo preparations and other controlled laboratory research applications including animal studies conducted under appropriate oversight.Typical uses include cell culture assays biochemical experiments on copper binding and transport and investigations of extracellular matrix remodeling and tissue biology. It is not intended for human or veterinary use. It is not intended for diagnosis treatment cure prevention or mitigation of any disease or cosmetic condition. It is not a drug food dietary supplement cosmetic ingredient or medical device.
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