Sin existencias
GHK-Cu 100 mg: Un complejo tripéptido-cobre utilizado en investigación de cultivo celular para estudiar la remodelación de la matriz extracelular, la angiogénesis y la señalización dependiente de cobre.
$115.00
Sin existencias
GHK Cu es un complejo metálico tripeptídico compuesto por glicil-L-histidil-L-lisina coordinado con iones de cobre divalente. Es un motivo de origen natural identificado en fluidos biológicos y entornos de matriz extracelular donde participa en la unión y entrega de cobre. Este producto se suministra como material de grado de investigación para laboratorios que estudian el manejo de metales mediado por péptidos, la señalización celular y la biología relacionada con la matriz.
La secuencia GHK (Gly-His-Lys) presenta alta afinidad por los iones de cobre y forma un complejo de coordinación definido con Cu²⁺ en condiciones fisiológicas. En sistemas experimentales, GHK Cu se utiliza para investigar cómo los complejos peptídicos de bajo peso molecular contribuyen a la homeostasis del cobre y a la regulación del comportamiento celular in vitro y en modelos animales in vivo. El trabajo científico con GHK Cu ha examinado sus interacciones con fibroblastos, células endoteliales, células inmunitarias y preparaciones neuronales. Los investigadores miden habitualmente cambios en la expresión génica, síntesis de proteínas, componentes de la matriz extracelular y activación de vías de señalización tras la exposición controlada a este complejo. Estos estudios posicionan GHK Cu como un compuesto herramienta para diseccionar respuestas celulares dependientes de cobre y la biología de complejos péptido-metal. Secuencia peptídica: Gly-His-Lys coordinada con Cu²⁺
Este producto está destinado exclusivamente a experimentos in vitro, preparaciones ex vivo y otras aplicaciones de investigación de laboratorio controladas, incluidos estudios en animales realizados bajo la supervisión apropiada. Los usos típicos incluyen ensayos de cultivo celular, experimentos bioquímicos sobre unión y transporte de cobre e investigaciones de remodelación de matriz extracelular y biología tisular.
No está destinado a uso humano ni veterinario. No está destinado al diagnóstico, tratamiento, curación, prevención o mitigación de ninguna enfermedad o afección cosmética. No es un medicamento, alimento, complemento alimenticio, ingrediente cosmético ni dispositivo médico.
Complejo de cobre tripeptídico GHK Cu definido, adecuado para estudios de unión y entrega de metales mediada por péptidos. Aplicable en investigación sobre respuestas de fibroblastos y células endoteliales, regulación de matriz extracelular y vías de señalización dependientes de cobre. Fabricado en condiciones controladas con verificación analítica de identidad, estequiometría y pureza.
GHK Cu is a tripeptide copper complex composed of glycyl histidyl lysine coordinated with divalent copper. It is widely used as a tool compound in cell and tissue models that examine copper handling extracellular matrix biology and regenerative signaling. The information below summarises how GHK Cu appears in the preclinical literature.
All observations are model specific and do not represent claims of cosmetic clinical or therapeutic effect.
A major use of GHK Cu is in dermal and connective tissue models that focus on fibroblast behavior. In these systems GHK Cu is used to study fibroblast migration proliferation and production of extracellular matrix components under controlled conditions. Typical endpoints include synthesis of collagen and other matrix proteins expression of matrix remodeling enzymes and modulation of adhesion molecules. Researchers use these readouts to map how peptide bound copper influences matrix turnover and tissue remodeling pathways in vitro and in animal models.
Endothelial cell assays represent a second core application. GHK Cu is applied to endothelial monolayers and three dimensional culture systems to probe changes in cell migration tube formation barrier properties and angiogenesis related signaling. These experiments often measure transcriptional and protein level responses in growth factors adhesion molecules and matrix interacting proteins. In this context GHK Cu serves as a tool to explore how low molecular weight copper complexes shape vascular and microvascular biology under defined experimental conditions.
GHK Cu has also been evaluated in models that involve immune cells and inflammatory signaling. Co culture systems and conditioned media experiments examine how fibroblasts or endothelial cells exposed to GHK Cu influence recruitment and activation of immune cells. Endpoints may include cytokine and chemokine profiles immune cell adhesion and migration and changes in markers of resolution or persistence of inflammation. These studies are designed to clarify how peptide mediated copper delivery intersects with immune related pathways in tissue environments.
Neuronal tissue and nerve related models use GHK Cu to investigate regeneration associated signaling. In these settings researchers monitor neurite outgrowth survival of neuronal cultures and expression of regeneration linked transcriptional programs in response to controlled GHK Cu exposure. This work remains preclinical and aims to define copper dependent cues that may influence neuronal plasticity and repair mechanisms.
Additional research explores GHK Cu in oxidative stress and host defense contexts. Studies examine how the complex interacts with reactive oxygen species handling systems and antioxidant enzymes and how it may modulate redox sensitive gene expression in cells. GHK Cu has also been studied alongside antimicrobial peptides and innate immune effectors to evaluate potential cooperative or modulatory effects in barrier tissues. These investigations focus on molecular and cellular endpoints rather than clinical infection outcomes.
Several experimental designs use GHK Cu to profile changes in stem cell associated markers and broad transcriptional responses related to tissue regeneration.
High throughput gene expression analyses and pathway enrichment approaches are common in this work. Researchers look for shifts in expression of genes involved in cell cycle control matrix organization growth factor signaling and developmental programs after GHK Cu treatment of relevant cell types. This positions GHK Cu as a probe for dissecting copper responsive transcriptional networks in regenerative contexts.
Across laboratories GHK Cu is commonly used in dermal fibroblast and extracellular matrix studies endothelial and angiogenesis assays immune cell recruitment and inflammation related models neuronal regeneration and plasticity studies oxidative stress and antimicrobial interface research transcriptional profiling of tissue regeneration pathways. In every case GHK Cu functions as a defined tripeptide copper complex for mechanistic research rather than as a finished product for cosmetic or medical use.
All findings described here arise from in vitro experiments ex vivo systems and animal studies conducted under controlled protocols. They are presented solely to inform qualified researchers about how GHK Cu is used as a laboratory tool. These observations do not demonstrate or imply that GHK Cu is safe or effective for any cosmetic dermatologic or medical indication. They are not dosing instructions product claims or guidance for clinical or aesthetic use. The GHK Cu product offered is intended strictly for laboratory research applications. It is not for human or veterinary use and must not be used for diagnosis treatment cure prevention or mitigation of any disease or cosmetic condition.
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